Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789464 | 0.93 | GPBAR1 (0.42) | GPBAR1NR1H4 | |
| SCHEMBL10277431 | 0.87 | GPBAR1 (0.44) | GPBAR1NR1H4 | |
| SCHEMBL15383111 | 0.84 | GPBAR1 (0.48) | GPBAR1NR1H4 | |
| SCHEMBL1986362 | 0.83 | GPBAR1 (0.47) | GPBAR1NR1H4 | |
| Hydrochloric Acid SCHEMBL1982221 | 0.82 | GPBAR1 (0.46) | GPBAR1NR1H4 | |
| SCHEMBL605233 | 0.80 | GPBAR1 (0.47) | GPBAR1NR1H4 | |
| SCHEMBL10274698 | 0.80 | GPBAR1 (0.43) | GPBAR1NR1H4 | |
| SCHEMBL603212 | 0.80 | GPBAR1 (0.43) | GPBAR1NR1H4 | |
| SCHEMBL3789499 | 0.79 | GPBAR1 (0.38) | GPBAR1 | |
| SCHEMBL604015 | 0.78 | GPBAR1 (0.54) | GPBAR1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396304-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | Exelixis, Inc. (US) | 2011-12-21 | — | — | EP | claimed |
| WO-2010093845-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | EXELIXIS, INC. (US) | 2010-08-19 | — | — | WO | claimed |