Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.65 |
| ▸ | BRD4 | O60885 | 13/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CCL2 | P13500 | 2/20 | 0.33 |
| ▸ | TAF1 | P21675 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077124 | 0.82 | AR (0.75) | ARBRD4KCNH2HRH3HTR1A | |
| SCHEMBL3067169 | 0.81 | AR (0.67) | ARBRD4KCNH2CCL2HTR1A | |
| SCHEMBL24592117 | 0.81 | AR (0.81) | ARBRD4KCNH2HRH3HTR1A | |
| SCHEMBL3077371 | 0.81 | AR (0.75) | ARBRD4KCNH2CCL2TAF1 | |
| SCHEMBL3068954 | 0.80 | AR (0.72) | ARBRD4KCNH2HRH3HTR1A | |
| SCHEMBL3075089 | 0.80 | AR (0.69) | ARBRD4KCNH2HRH3HTR1A | |
| SCHEMBL3068554 | 0.80 | AR (0.67) | ARBRD4KCNH2CCL2TAF1 | |
| SCHEMBL3069348 | 0.80 | AR (0.67) | ARBRD4KCNH2CCL2TAF1 | |
| SCHEMBL3065313 | 0.80 | AR (0.68) | ARBRD4KCNH2HRH3HTR1A | |
| SCHEMBL3071341 | 0.80 | AR (0.66) | ARBRD4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396333-A1 | TRIAZOLO [4,3-B]PYRIDAZINE DERIVATIVES AND THEIR USES FOR PROSTATE CANCER | AstraZeneca AB (SE) | 2011-12-21 | — | — | EP | claimed |
| WO-2010092371-A1 | TRIAZOLO [4,3-B] PYRIDAZINE DERIVATIVES AND THEIR USES FOR PROSTATE CANCER | ASTRAZENECA AB (SE) | 2010-08-19 | — | — | WO | claimed |