Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 20/20 | 0.88 |
| ▸ | DRD3 | P35462 | 19/20 | 0.88 |
| ▸ | DRD2 | P14416 | 16/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394165 | 1.00 | KCNH2 (0.88) | KCNH2DRD3DRD2 | |
| SCHEMBL378317 | 1.00 | KCNH2 (0.88) | KCNH2DRD3DRD2 | |
| SCHEMBL378984 | 1.00 | KCNH2 (0.88) | KCNH2DRD3DRD2 | |
| SCHEMBL13079521 | 1.00 | KCNH2 (0.88) | KCNH2DRD3DRD2 | |
| SCHEMBL11911780 | 1.00 | KCNH2 (0.88) | KCNH2DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL378459 | 0.99 | KCNH2 (0.86) | KCNH2DRD3DRD2 | |
| SCHEMBL5245524 | 0.94 | KCNH2 (1.00) | KCNH2DRD3DRD2 | |
| SCHEMBL5245984 | 0.94 | KCNH2 (1.00) | KCNH2DRD3DRD2 | |
| SCHEMBL378384 | 0.94 | KCNH2 (1.00) | KCNH2DRD3DRD2 | |
| SCHEMBL5245761 | 0.94 | KCNH2 (1.00) | KCNH2DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2060570-B1 | Azabicyclo[3.1.0] hexane derivatives useful as modulators of dopamine D3 receptors | GLAXO GROUP LTD (GB) | 2012-01-25 | — | — | EP | claimed |