Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.56 |
| ▸ | FLT1 | P17948 | 8/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | YES1 | P07947 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378488 | 0.98 | KDR (0.54) | KDRFLT1PDGFRBPLK4AURKA | |
| SCHEMBL378524 | 0.95 | KDR (0.55) | KDRFLT1PDGFRBPLK4AURKA | |
| SCHEMBL378604 | 0.95 | KDR (0.63) | KDRFLT1PDGFRBPLK4AURKA | |
| SCHEMBL378139 | 0.93 | KDR (0.60) | KDRFLT1PDGFRBPLK4AURKA | |
| SCHEMBL378769 | 0.93 | KDR (0.52) | KDRFLT1PDGFRBPLK4AURKA | |
| SCHEMBL378617 | 0.91 | KDR (0.56) | KDRFLT1PDGFRBPLK4AURKA | |
| SCHEMBL378471 | 0.91 | KDR (0.50) | KDRFLT1PDGFRBPLK4AURKA | |
| SCHEMBL378726 | 0.89 | KDR (0.70) | KDRFLT1PDGFRBPLK4AURKA | |
| SCHEMBL4845454 | 0.89 | KDR (0.69) | KDRFLT1PDGFRBPLK4AURKA | |
| SCHEMBL3079528 | 0.89 | KDR (0.69) | KDRFLT1PDGFRBPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784183-B1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER (US) | 2012-01-25 | — | — | EP | claimed |
| EP-1545519-B1 | COMBINATION THERAPY FOR HYPERPROLIFERATIVE DISEASES | PFIZER (US) | 2011-03-23 | — | — | EP | claimed |
| EP-1084114-B1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PROD INC (US) | 2004-09-08 | — | — | EP | claimed |