Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 14/20 | 0.58 |
| ▸ | CDC7 | O00311 | 13/20 | 0.58 |
| ▸ | DBF4 | Q9UBU7 | 13/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.58 |
| ▸ | CDK2 | P24941 | 13/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613680 | 0.89 | ROCK1 (0.60) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613701 | 0.86 | CDC7 (0.66) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613816 | 0.85 | ROCK1 (0.59) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613656 | 0.84 | ROCK1 (0.62) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613682 | 0.83 | ROCK1 (0.59) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613280 | 0.83 | CDC7 (0.70) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL612621 | 0.82 | CDC7 (0.62) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL612136 | 0.81 | ROCK1 (0.70) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL612014 | 0.81 | ROCK1 (0.61) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL614242 | 0.81 | ROCK1 (0.66) | ROCK1CDC7DBF4CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101302-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-10 | — | — | WO | disclosed |