Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 18/20 | 0.46 |
| ▸ | PDCD1LG2 | Q9BQ51 | 13/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL864022 | 1.00 | CD274 (0.46) | CD274PDCD1LG2IRAK4PDCD1IRAK1 | |
| SCHEMBL864023 | 1.00 | CD274 (0.46) | CD274PDCD1LG2IRAK4PDCD1IRAK1 | |
| SCHEMBL865397 | 0.83 | PIK3CD (0.41) | CD274PDCD1LG2IRAK4PDCD1IRAK1 | |
| SCHEMBL864057 | 0.83 | CD274 (0.38) | CD274PDCD1LG2IRAK4PDCD1IRAK1 | |
| SCHEMBL864056 | 0.83 | CD274 (0.38) | CD274PDCD1LG2IRAK4PDCD1IRAK1 | |
| SCHEMBL865396 | 0.83 | PIK3CD (0.41) | CD274PDCD1LG2IRAK4PDCD1IRAK1 | |
| SCHEMBL863494 | 0.82 | PIK3CD (0.44) | CD274PDCD1LG2IRAK4PDCD1IRAK1 | |
| SCHEMBL863495 | 0.82 | PIK3CD (0.44) | CD274PDCD1LG2IRAK4PDCD1IRAK1 | |
| SCHEMBL864019 | 0.81 | PIK3CD (0.40) | CD274PDCD1LG2IRAK4PDCD1IRAK1 | |
| SCHEMBL864020 | 0.81 | PIK3CD (0.40) | CD274PDCD1LG2IRAK4PDCD1IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396315-A1 | FUSED PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092340-A1 | FUSED PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-08-19 | — | — | WO | disclosed |