Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14637632 | 0.75 | ACE (0.31) | ACE | |
| SCHEMBL27915638 | 0.71 | GRIN1 (0.32) | — | |
| SCHEMBL27915646 | 0.71 | GRIN1 (0.32) | — | |
| SCHEMBL27915691 | 0.71 | GRIN1 (0.32) | — | |
| SCHEMBL8695787 | 0.70 | HPGD (0.31) | — | |
| SCHEMBL26136295 | 0.68 | DPP4 (0.31) | — | |
| SCHEMBL15319783 | 0.67 | TSHR (0.39) | — | |
| SCHEMBL26696808 | 0.66 | ACE (0.35) | ACE | |
| SCHEMBL17180833 | 0.66 | ACE (0.33) | ACE | |
| SCHEMBL28612834 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142537-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008115973-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-25 | — | — | WO | disclosed |