Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2748849 | 0.85 | CDK8 (0.50) | CDK1CDK2MKNK1MKNK2TP53 | |
| SCHEMBL2747422 | 0.81 | MAP4K4 (0.58) | CDK1CDK2MKNK1MKNK2ALDH1A1 | |
| SCHEMBL2750391 | 0.80 | MAP4K4 (0.42) | CDK1CDK2MKNK1MKNK2TP53 | |
| SCHEMBL2750253 | 0.80 | FYN (0.54) | FGFR1FGFR3CDK1CDK2MKNK1 | |
| SCHEMBL2749406 | 0.79 | ATR (0.58) | TP53KDM4ENPC1RAB9AKMT2A | |
| SCHEMBL2747417 | 0.79 | CDK8 (0.49) | CDK1CDK2MKNK1MKNK2TP53 | |
| SCHEMBL2749016 | 0.78 | FYN (0.51) | CDK1CDK2MKNK1MKNK2TP53 | |
| SCHEMBL2749692 | 0.77 | FYN (0.45) | CDK1CDK2MKNK1MKNK2ALDH1A1 | |
| SCHEMBL2749695 | 0.77 | FYN (0.45) | CDK1CDK2MKNK1MKNK2ALDH1A1 | |
| SCHEMBL2750442 | 0.77 | ATR (0.55) | TP53ALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |