Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063593 | 0.93 | MAP2K1 (0.39) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063782 | 0.92 | MAP2K1 (0.38) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063529 | 0.92 | MAP2K1 (0.44) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL3803379 | 0.90 | MAP2K1 (0.37) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL3807052 | 0.90 | MAP2K1 (0.38) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063784 | 0.90 | MAP2K1 (0.39) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063575 | 0.90 | MAP2K1 (0.38) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063564 | 0.89 | MAP2K1 (0.39) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063579 | 0.88 | MAP2K1 (0.38) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063598 | 0.87 | MAP2K1 (0.38) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |