Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.72 |
| ▸ | CCND1 | P24385 | 5/20 | 0.72 |
| ▸ | CDK1 | P06493 | 5/20 | 0.72 |
| ▸ | CCND3 | P30281 | 4/20 | 0.72 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.72 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.72 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.72 |
| ▸ | CDK2 | P24941 | 3/20 | 0.72 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.72 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108773 | 0.87 | CDK4 (0.73) | CDK4CCND1CDK1CCND3CDK6 | |
| SCHEMBL112922 | 0.84 | CDK4 (0.73) | CDK4CCND1CDK1CCND3CDK6 | |
| SCHEMBL111812 | 0.80 | CDK4 (0.89) | CDK4CCND1CDK1CCND3CDK6 | |
| Hydrochloric Acid SCHEMBL175288 | 0.79 | CDK4 (0.87) | CDK4CCND1CDK1CCND3CDK6 | |
| SCHEMBL114340 | 0.78 | CDK4 (0.84) | CDK4CCND1CDK1CCND3CDK6 | |
| SCHEMBL2129207 | 0.76 | CDK4 (0.78) | CDK4CCND1CDK1CCND3CDK6 | |
| SCHEMBL110592 | 0.75 | CDK4 (0.77) | CDK4CCND1CDK1CCND3CDK6 | |
| SCHEMBL111954 | 0.75 | CDK4 (1.00) | CDK4CCND1CDK1CCND3CDK6 | |
| SCHEMBL109669 | 0.74 | CDK4 (0.79) | CDK4CCND1CDK1CCND3CDK6 | |
| SCHEMBL111810 | 0.74 | CDK4 (0.83) | CDK4CCND1CDK1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | claimed |