Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.59 |
| ▸ | LYN | P07948 | 9/20 | 0.59 |
| ▸ | SRC | P12931 | 9/20 | 0.59 |
| ▸ | KDR | P35968 | 9/20 | 0.59 |
| ▸ | HCK | P08631 | 8/20 | 0.59 |
| ▸ | BRAF | P15056 | 8/20 | 0.52 |
| ▸ | INSR | P06213 | 7/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374255 | 0.95 | LCK (0.64) | LCKLYNSRCKDRHCK | |
| SCHEMBL374496 | 0.93 | LCK (0.67) | LCKLYNSRCKDRHCK | |
| SCHEMBL374317 | 0.86 | LCK (0.65) | LCKLYNSRCKDRHCK | |
| SCHEMBL374341 | 0.83 | LCK (0.67) | LCKLYNSRCKDRHCK | |
| SCHEMBL14550183 | 0.83 | LCK (0.63) | LCKLYNSRCKDRHCK | |
| SCHEMBL373994 | 0.83 | LCK (0.63) | LCKLYNSRCKDRHCK | |
| SCHEMBL374410 | 0.83 | LCK (0.66) | LCKLYNSRCKDRHCK | |
| SCHEMBL374451 | 0.82 | LCK (0.66) | LCKLYNSRCKDRHCK | |
| SCHEMBL374179 | 0.81 | LCK (0.67) | LCKLYNSRCKDRHCK | |
| SCHEMBL374545 | 0.81 | LCK (0.68) | LCKSRCKDRBRAFCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409969-A1 | Pyrimidine urea derivatives as kinase inhibitors | Novartis AG (CH) | 2012-01-25 | — | — | EP | claimed |