Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 5/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | DKK1 | O94907 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208254 | 0.86 | POLB (0.58) | POLBKDM4ECYP2C19HDAC6HDAC3 | |
| SCHEMBL15341332 | 0.85 | POLB (0.56) | POLBKDM4ECYP2C19HDAC6HDAC3 | |
| SCHEMBL20046278 | 0.84 | POLB (0.55) | POLBKDM4ECYP2C19HDAC6HDAC3 | |
| SCHEMBL9883418 | 0.83 | OGA (0.45) | KDM4EAKT2HDAC6HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL21615911 | 0.82 | OGA (0.44) | KDM4EAKT2HDAC6HDAC3HDAC4 | |
| SCHEMBL25141688 | 0.81 | POLB (0.52) | POLBKDM4ECYP2C19HDAC6HDAC3 | |
| SCHEMBL649475 | 0.81 | OGA (0.47) | POLBKDM4EHDAC6HDAC1KDM1A | |
| SCHEMBL20046345 | 0.81 | POLB (0.51) | POLBKDM4ECYP2C19HDAC6HDAC3 | |
| SCHEMBL25141729 | 0.81 | POLB (0.51) | POLBKDM4ECYP2C19HDAC6HDAC3 | |
| SCHEMBL1270475 | 0.80 | POLB (0.61) | POLBKDM4ECYP2C19KDM1AOGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9636341-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-05-02 | — | — | US | disclosed |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-03 | — | — | US | disclosed |
| US-9150543-B2 | Substituted indolyl alkyl amino derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N. V. (BE) | 2015-10-06 | — | — | US | disclosed |
| CN-102341108-B | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH ZINC BINDING MOIETY | CURIS INC | 2015-05-27 | — | — | CN | disclosed |
| US-20140309248-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-10-16 | — | — | US | disclosed |
| EP-1981875-B1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-16 | — | — | EP | disclosed |
| US-20130324568-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-12-05 | — | — | US | disclosed |
| US-8592441-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-11-26 | — | — | US | disclosed |
| US-8524728-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-09-03 | — | — | US | disclosed |
| CN-102970868-A | Treatment of cancers having K-RAS mutations | CURIS INC | 2013-03-13 | — | — | CN | disclosed |
| EP-1981871-A1 | HETEROCYCLYLALKYL DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | Janssen Pharmaceutica, N.V. (BE) | 2008-10-22 | — | — | EP | disclosed |
| EP-1981875-A1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | Janssen Pharmaceutica, N.V. (BE) | 2008-10-22 | — | — | EP | disclosed |
| EP-1979328-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | Janssen Pharmaceutica, N.V. (BE) | 2008-10-15 | — | — | EP | disclosed |
| EP-1899325-A1 | IMIDAZOLINONE AND HYDANTOINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007082880-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007082882-A1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007082873-A1 | HETEROCYCLYLALKYL DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-26 | — | — | WO | disclosed |
| EP-1781639-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006136553-A1 | IMIDAZOLINONE AND HYDANTOINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006010750-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309248-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | POLB 619/4885KDM4E 82/4885CYP2C19 2711/4885 |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | POLB 729/4885KDM4E 85/4885CYP2C19 2782/4885 |
| US-20130324568-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | POLB 729/4885KDM4E 85/4885CYP2C19 2782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.