Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 17/20 | 0.49 |
| ▸ | LCK | P06239 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2217167 | 0.89 | MAPKAPK5 (0.56) | MAPKAPK5PTK6LCKAURKB | |
| SCHEMBL3794125 | 0.85 | MAPKAPK5 (0.57) | MAPKAPK5PTK6LCKAURKB | |
| SCHEMBL2217389 | 0.83 | MAPKAPK5 (0.59) | MAPKAPK5PTK6LCKAURKB | |
| SCHEMBL14369554 | 0.83 | MAPKAPK5 (0.55) | MAPKAPK5PTK6LCKAURKB | |
| SCHEMBL2216055 | 0.82 | MAPKAPK5 (0.62) | MAPKAPK5PTK6LCKAURKB | |
| SCHEMBL2218407 | 0.81 | MAPKAPK5 (0.53) | MAPKAPK5PTK6LCKAURKB | |
| SCHEMBL2217385 | 0.81 | MAPKAPK5 (0.68) | MAPKAPK5PTK6LCKAURKB | |
| SCHEMBL2220116 | 0.80 | MAPKAPK5 (0.60) | MAPKAPK5PTK6LCKAURKB | |
| SCHEMBL2218488 | 0.80 | MAPKAPK5 (0.56) | MAPKAPK5PTK6LCKAURKB | |
| SCHEMBL3793678 | 0.80 | MAPKAPK5 (0.56) | MAPKAPK5PTK6LCKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |