Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330740 | 0.82 | PDE4B (0.53) | PDE4BPDE4D | |
| SCHEMBL3788986 | 0.82 | PDE4D (0.58) | PDE4BPDE4DMAPK9MAPK10MAPK14 | |
| SCHEMBL8067088 | 0.82 | PDE4D (0.58) | PDE4BPDE4DMAPK9MAPK10MAPK14 | |
| Hydrochloric Acid SCHEMBL4333031 | 0.81 | PDE4D (0.57) | PDE4BPDE4DMAPK9MAPK10MAPK14 | |
| SCHEMBL3795876 | 0.79 | PDE4D (0.55) | PDE4BPDE4DMAPK9MAPK10MAPK14 | |
| SCHEMBL4325690 | 0.79 | PDE4B (0.50) | PDE4BPDE4DTNIKMAPK10 | |
| SCHEMBL7911614 | 0.78 | PDE4D (0.60) | PDE4BPDE4DMAPK10 | |
| SCHEMBL3466293 | 0.78 | PDE4D (0.57) | PDE4BPDE4DMAPK9MAPK10MAPK14 | |
| SCHEMBL7917989 | 0.76 | PDE4D (0.59) | PDE4BPDE4DMAPK10 | |
| SCHEMBL3806088 | 0.76 | PDE4B (0.64) | PDE4BPDE4DTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222638-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |