Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | GLP1R | P43220 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14357206 | 0.81 | KMT2A (0.44) | KMT2ACYP1A2CA9GAAKDM4E | |
| SCHEMBL574088 | 0.80 | NPC1 (0.51) | KMT2ACYP1A2GAAKDM4EMAPT | |
| SCHEMBL9079717 | 0.79 | CYP1A2 (0.45) | KMT2ANR1H2CYP1A2CA9GAA | |
| SCHEMBL15458737 | 0.78 | CYP1A2 (0.44) | KMT2ACYP1A2GAATP53KDM4E | |
| SCHEMBL13278694 | 0.74 | DYRK1A (0.42) | KMT2ANR1H2CHRNA7CYP1A2CA9 | |
| SCHEMBL1232533 | 0.73 | KMT2A (0.40) | KMT2ACYP1A2GAATP53KDM4E | |
| SCHEMBL17259226 | 0.73 | KMT2A (0.40) | KMT2ANR1H2CYP1A2GAATP53 | |
| SCHEMBL17259224 | 0.73 | CHRNA7 (0.58) | NR1H2CHRNA7CA9KDM4EMAPT | |
| SCHEMBL4016328 | 0.72 | CA9 (0.57) | KMT2ANR1H2CA9GAAMAPT | |
| SCHEMBL28913938 | 0.71 | KMT2A (0.41) | KMT2ANR1H2CYP1A2CA9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146716-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008131227-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |