Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12430835 | 0.96 | TSHR (0.41) | TSHRALDH1A1THRBTGFBR1PDE4A | |
| SCHEMBL2032167 | 0.96 | TSHR (0.41) | TSHRALDH1A1THRBTGFBR1PDE4A | |
| SCHEMBL6014081 | 0.92 | TSHR (0.42) | TSHRALDH1A1THRBTGFBR1 | |
| SCHEMBL12585313 | 0.89 | TSHR (0.36) | TSHRALDH1A1THRBTGFBR1 | |
| SCHEMBL13670752 | 0.84 | TSHR (0.33) | TSHRALDH1A1 | |
| SCHEMBL11710808 | 0.83 | TSHR (0.41) | TSHRALDH1A1THRBTGFBR1PDE4A | |
| SCHEMBL2489434 | 0.83 | TSHR (0.33) | TSHRALDH1A1 | |
| SCHEMBL13576992 | 0.83 | TSHR (0.33) | TSHRALDH1A1 | |
| SCHEMBL2489327 | 0.83 | TSHR (0.33) | TSHRALDH1A1 | |
| SCHEMBL2491057 | 0.83 | TSHR (0.33) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273802-B2 | Silicones formed from an oxygen permeable component and a vinyl carbonate, carbamate ester or amide beta-substituted vinyl pyrrolidone; improve wettability of the lens without a surface treatment | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| EP-1890171-B1 | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents | JOHNSON & JOHNSON VISION CARE (US) | 2010-12-22 | — | — | EP | disclosed |
| CN-100578263-C | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents | JOHNSON & JOHNSON VISION CARE | 2010-01-06 | — | — | CN | disclosed |
| US-20080275156-A1 | WETTABLE HYDROGELS COMPRISING REACTIVE, HYDROPHILIC, POLYMERIC INTERNAL WETTING AGENTS | JOHNSON & JOHNSON VISION CARE, INC. | 2008-11-06 | — | — | US | disclosed |
| US-20080197324-A1 | OPHTHALMIC COMPOSITION CONTAINING A POLYOL-ACID COPOLYMER | BAUSCH & LOMB INCORPORATED | 2008-08-21 | — | — | US | disclosed |
| EP-1800150-B1 | WETTABLE HYDROGELS COMPRISING REACTIVE, HYDROPHILIC, POLYMERIC INTERNAL WETTING AGENTS | JOHNSON & JOHNSON VISION CARE (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1890171-A2 | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents | Johnson & Johnson Vision Care, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| US-20070264503-A1 | Polymers comprising polyhydric alcohols, medical devices modified with same, and method of making | BAUSCH & LOMB INCORPORATED | 2007-11-15 | — | — | US | disclosed |
| US-20070264509-A1 | Copolymer and Medical Device with the Copolymer | BAUSCH & LOMB INCORPORATED | 2007-11-15 | — | — | US | disclosed |
| CN-101065686-A | Wettable hydrogels containing reactive hydrophilic polymeric internal wetting agents | JOHNSON & JOHNSON VISION CARE (US) | 2007-10-31 | — | — | CN | disclosed |
| US-7249848-B2 | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2007-07-31 | — | — | US | disclosed |
| EP-1800150-A1 | WETTABLE HYDROGELS COMPRISING REACTIVE, HYDROPHILIC, POLYMERIC INTERNAL WETTING AGENTS | Johnson & Johnson Vision Care, Inc. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006039466-A1 | WETTABLE HYDROGELS COMPRISING REACTIVE, HYDROPHILIC, POLYMERIC INTERNAL WETTING AGENTS | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2006-04-13 | — | — | WO | disclosed |
| US-20060072069-A1 | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents | JOHNSON & JOHNSON VISION CARE, INC. | 2006-04-06 | — | — | US | disclosed |