Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951375 | 0.78 | EPHX2 (0.44) | GAAATMALDH1A1KDM4E | |
| SCHEMBL5972069 | 0.77 | GAA (0.58) | GAAATMKMT2AALDH1A1POLB | |
| SCHEMBL15006750 | 0.76 | POLB (0.46) | KMT2AALDH1A1POLBTDP1MAPT | |
| SCHEMBL1321565 | 0.74 | GAA (0.58) | GAAATMKMT2AALDH1A1POLB | |
| SCHEMBL27577402 | 0.71 | POLB (0.44) | GAAKMT2AALDH1A1POLBTDP1 | |
| SCHEMBL8322750 | 0.71 | ATM (0.45) | GAAATMKMT2AALDH1A1POLB | |
| SCHEMBL27765467 | 0.70 | GAA (1.00) | GAAATMKMT2AALDH1A1MAPT | |
| SCHEMBL2556638 | 0.70 | POLB (0.63) | GAAATMKMT2AALDH1A1POLB | |
| SCHEMBL17802298 | 0.69 | GRIA1 (0.57) | KMT2AALDH1A1POLBTDP1MAPT | |
| SCHEMBL1321811 | 0.69 | KMT2A (0.74) | GAAATMKMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010117090-A1 | NOVEL ISOQUINOLINYLOXYMETHYL HETEROARYL DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-10-14 | — | — | WO | disclosed |