Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.53 |
| ▸ | IGF1R | P08069 | 3/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCND3 | P30281 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | WEE1 | P30291 | 5/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | PAK4 | O96013 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800808 | 0.94 | EGFR (0.53) | EGFRIGF1RNTRK1CDK9CCNK | |
| SCHEMBL3761412 | 0.80 | KDM1A (0.42) | EGFRIGF1RNTRK1CDK9CCNK | |
| SCHEMBL3771267 | 0.78 | EGFR (0.54) | EGFRIGF1RNTRK1CDK9CCNK | |
| SCHEMBL3759654 | 0.75 | EGFR (0.83) | EGFRIGF1RNTRK1CDK9WEE1 | |
| SCHEMBL3761466 | 0.75 | KDM1A (0.42) | NTRK1CDK9CCNKCCNA2CDK2 | |
| SCHEMBL3274766 | 0.73 | IGF1R (0.77) | EGFRIGF1RCDK9CCNKCCNA2 | |
| SCHEMBL3769145 | 0.73 | WEE1 (0.62) | EGFRIGF1RNTRK1CDK9WEE1 | |
| SCHEMBL15797629 | 0.72 | EGFR (0.58) | EGFRIGF1RCDK9CCNKCCNA2 | |
| SCHEMBL30270089 | 0.71 | CYP11B1 (0.52) | ERBB2BRD4 | |
| SCHEMBL655906 | 0.71 | SYK (0.65) | EGFRIGF1RNTRK1CDK9CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138578-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |