Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 18/20 | 0.70 |
| ▸ | RAF1 | P04049 | 1/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379717 | 0.99 | MAPK13 (0.72) | MAPK13RAF1MAPK14RIPK2 | |
| SCHEMBL379848 | 0.91 | MAPK13 (0.73) | MAPK13RAF1MAPK14RIPK2 | |
| SCHEMBL380014 | 0.84 | MAPK13 (0.94) | MAPK13RAF1MAPK14 | |
| SCHEMBL380900 | 0.84 | MAPK13 (0.66) | MAPK13RAF1MAPK14RIPK2 | |
| SCHEMBL379661 | 0.83 | MAPK13 (0.76) | MAPK13RAF1MAPK14 | |
| SCHEMBL380252 | 0.83 | MAPK13 (0.96) | MAPK13RAF1MAPK14 | |
| SCHEMBL3616014 | 0.83 | MAPK13 (1.00) | MAPK13RAF1MAPK14 | |
| SCHEMBL379884 | 0.82 | MAPK13 (1.00) | MAPK13RAF1MAPK14 | |
| SCHEMBL379524 | 0.82 | MAPK13 (0.76) | MAPK13RAF1MAPK14 | |
| SCHEMBL380693 | 0.82 | MAPK13 (1.00) | MAPK13RAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-B1 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC (US) | 2012-01-25 | — | — | EP | disclosed |