Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.39 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802315 | 0.82 | HSP90AA1 (0.51) | ALDH1A1KDM4EHPGDHSP90AA1MEN1 | |
| SCHEMBL3801644 | 0.79 | HSP90AA1 (0.47) | HSP90AA1 | |
| SCHEMBL3797850 | 0.78 | HSP90AA1 (0.54) | HSP90AA1 | |
| SCHEMBL3799341 | 0.77 | HSP90AA1 (0.59) | HSP90AA1 | |
| SCHEMBL3801566 | 0.77 | HSP90AA1 (0.70) | HSP90AA1 | |
| SCHEMBL3797209 | 0.75 | HSP90AA1 (0.41) | HSP90AA1 | |
| SCHEMBL3795008 | 0.74 | HSP90AA1 (0.57) | HSP90AA1 | |
| SCHEMBL3795551 | 0.69 | HSP90AA1 (0.52) | HSP90AA1 | |
| SCHEMBL22776640 | 0.68 | NR4A2 (0.46) | NR4A2BRD4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29526905 | 0.68 | NR4A2 (0.46) | NR4A2BRD4ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010117425-A1 | CERTAIN SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | BIOGEN IDEC MA INC. (US) | 2010-10-14 | — | — | WO | disclosed |