Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 13/20 | 0.65 |
| ▸ | PSEN2 | P49810 | 13/20 | 0.65 |
| ▸ | APH1B | Q8WW43 | 13/20 | 0.65 |
| ▸ | NCSTN | Q92542 | 13/20 | 0.65 |
| ▸ | APH1A | Q96BI3 | 13/20 | 0.65 |
| ▸ | PSENEN | Q9NZ42 | 13/20 | 0.65 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12126921 | 0.90 | PSEN1 (0.68) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1336503 | 0.90 | PSEN1 (0.68) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29536448 | 0.90 | PSEN1 (0.68) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1338727 | 0.84 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15693566 | 0.84 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12126925 | 0.84 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8246926 | 0.81 | PSEN1 (0.70) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8257641 | 0.80 | PSEN1 (0.83) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1337538 | 0.79 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13742162 | 0.79 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393776-A1 | NOVEL TRIFLUOROMETHYLSULFONAMIDE GAMMA SECRETASE INHIBITOR | Merck Sharp & Dohme Corp. (US) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010090954-A1 | NOVEL TRIFLUOROMETHYLSULFONAMIDE GAMMA SECRETASE INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2010-08-12 | — | — | WO | disclosed |