Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.74 |
| ▸ | KDR | P35968 | 9/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.58 |
| ▸ | FLT1 | P17948 | 3/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | FYN | P06241 | 2/20 | 0.58 |
| ▸ | CSF1R | P07333 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.58 |
| ▸ | AXL | P30530 | 2/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.58 |
| ▸ | ABL2 | P42684 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800843 | 1.00 | AURKA (0.74) | AURKAKDRPDGFRBFGFR1FLT1 | |
| SCHEMBL3800157 | 0.85 | AURKA (1.00) | AURKAKDRPDGFRBFGFR1FLT1 | |
| SCHEMBL3800161 | 0.85 | AURKA (1.00) | AURKAKDRPDGFRBFGFR1FLT1 | |
| SCHEMBL3798305 | 0.83 | AURKA (0.64) | AURKAKDRFGFR1PTK2BSRC | |
| SCHEMBL3798297 | 0.83 | AURKA (0.64) | AURKAKDRFGFR1PTK2BSRC | |
| SCHEMBL3794353 | 0.82 | SRC (0.60) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL3794357 | 0.82 | SRC (0.60) | AURKAKDRPDGFRBFGFR1ALK | |
| SCHEMBL12792855 | 0.82 | AURKA (0.72) | AURKAKDRPDGFRBFGFR1SRC | |
| SCHEMBL3798726 | 0.82 | AURKA (0.75) | AURKAKDRPDGFRBFGFR1SRC | |
| SCHEMBL3798721 | 0.82 | AURKA (0.75) | AURKAKDRPDGFRBFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897602-B2 | Indolinone compounds as kinase inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2011-03-01 | — | — | US | claimed |
| US-20100179146-A1 | Indolinone Compounds as Kinase Inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2010-07-15 | — | — | US | claimed |
| US-7897602-B2 | Indolinone compounds as kinase inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2011-03-01 | — | — | US | disclosed |
| US-20100179146-A1 | Indolinone Compounds as Kinase Inhibitors | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179146-A1 | Indolinone Compounds as Kinase Inhibitors | CDK2, MAP3K19, MAP3K20 | AURKA 96/4885KDR 853/4885PDGFRB 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.