Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | OGG1 | O15527 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933209 | 0.81 | PDE2A (0.46) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL16243838 | 0.75 | MEN1 (0.41) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL2130948 | 0.75 | CA1 (0.42) | MEN1KMT2ANPC1RAB9ACA1 | |
| SCHEMBL16243709 | 0.74 | HDAC3 (0.43) | MEN1KMT2ANPC1RAB9ALMNA | |
| Benzoquinone SCHEMBL28257947 | 0.74 | PDE2A (0.44) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL25207178 | 0.73 | MEN1 (0.42) | MEN1KMT2ANPC1RAB9ACA1 | |
| SCHEMBL30885354 | 0.71 | CA1 (0.42) | CA1CA2CA5ACA9OGG1 | |
| SCHEMBL2130309 | 0.70 | KMT2A (0.46) | MEN1KMT2ANPC1RAB9ACA1 | |
| SCHEMBL22938368 | 0.70 | PDE2A (0.44) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL1845922 | 0.70 | MEN1 (0.40) | MEN1KMT2ANPC1RAB9ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209771-A1 | CYCLOBUTYL CARBOXYLIC ACID DERIVATIVES | Pfizer, Inc. (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009060278-A1 | CYCLOBUTYL CARBOXYLIC ACID DERIVATIVES | PFIZER INC. (US) | 2009-05-14 | — | — | WO | disclosed |
| EP-1756042-A1 | SUBSTITUTED METHYL ARYL OR HETEROARYL AMIDE COMPOUNDS | Pfizer, Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105732-A1 | SUBSTITUTED METHYL ARYL OR HETEROARYL AMIDE COMPOUNDS | PFIZER JAPAN INC. (JP) | 2005-11-10 | — | — | WO | disclosed |