Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.59 |
| ▸ | CCND1 | P24385 | 6/20 | 0.59 |
| ▸ | CCND3 | P30281 | 5/20 | 0.59 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.59 |
| ▸ | CDK1 | P06493 | 3/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.59 |
| ▸ | CDK2 | P24941 | 4/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113002 | 0.95 | CDK4 (0.65) | CDK4CCND1CCND3CDK6CDK1 | |
| SCHEMBL112816 | 0.94 | CDK4 (0.66) | CDK4CCND1CCND3CDK6CDK1 | |
| SCHEMBL112265 | 0.89 | CDK4 (0.65) | CDK4CCND1CCND3CDK6CDK1 | |
| SCHEMBL110865 | 0.84 | CDK4 (0.67) | CDK4CCND1CCND3CDK6CDK1 | |
| SCHEMBL110212 | 0.84 | CDK4 (0.67) | CDK4CCND1CCND3CDK6CDK1 | |
| SCHEMBL111784 | 0.80 | CDK4 (0.64) | CDK4CCND1CCND3CDK6CDK1 | |
| SCHEMBL111163 | 0.80 | CDK4 (0.68) | CDK4CCND1CCND3CDK6CDK1 | |
| Hydrochloric Acid SCHEMBL2143329 | 0.79 | CDK4 (0.67) | CDK4CCND1CCND3CDK6CDK1 | |
| SCHEMBL111341 | 0.79 | CDK4 (0.64) | CDK4CCND1CCND3CDK6CDK1 | |
| SCHEMBL113756 | 0.78 | CDK4 (0.65) | CDK4CCND1CCND3CDK6CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | claimed |