Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 18/20 | 0.55 |
| ▸ | LMNA | P02545 | 13/20 | 0.55 |
| ▸ | THRB | P10828 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324760 | 0.83 | MAPT (0.67) | MAPTLMNATHRBPOLBTP53 | |
| SCHEMBL3323572 | 0.73 | POLB (0.66) | MAPTLMNATHRBPOLBTP53 | |
| SCHEMBL3322285 | 0.73 | MAPT (0.60) | MAPTLMNATHRBPOLB | |
| SCHEMBL3322434 | 0.70 | MAPT (0.67) | MAPTLMNATHRBPOLBTP53 | |
| SCHEMBL3325481 | 0.68 | MAPT (0.64) | MAPTLMNATHRBPOLBTP53 | |
| SCHEMBL3323736 | 0.68 | MAPT (0.73) | MAPTLMNATHRBPOLBTP53 | |
| SCHEMBL3324864 | 0.67 | MAPT (0.71) | MAPTLMNATHRBPOLBTP53 | |
| SCHEMBL3320451 | 0.62 | MAPT (0.71) | MAPTLMNATHRBPOLBTP53 | |
| SCHEMBL13980952 | 0.62 | MAPT (0.54) | MAPTLMNATHRBPOLBTP53 | |
| SCHEMBL3324720 | 0.61 | MAPT (0.70) | MAPTLMNATHRBPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139472-A1 | TETRAHYDROINDOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYO TEX SA (CH) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116926-A1 | TETRAHYDROINDOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYO TEX SA (CH) | 2008-10-02 | — | — | WO | disclosed |