Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855715 | 0.92 | PIK3CA (0.46) | PIK3CAPDE10AALKBH3HIF1ACREBBP | |
| SCHEMBL856634 | 0.92 | PIK3CA (0.43) | PIK3CAFGFR1FGFR2FGFR3KDR | |
| SCHEMBL856995 | 0.91 | PIK3CA (0.45) | PIK3CAPDE10AALKBH3ALDH1A1HIF1A | |
| SCHEMBL861032 | 0.91 | PIK3CA (0.47) | PIK3CAPDE10AALKBH3CREBBPPIK3CD | |
| SCHEMBL858375 | 0.91 | PIK3CA (0.46) | PIK3CAGAAALKBH3ALDH1A1MEN1 | |
| SCHEMBL856627 | 0.89 | PIK3CA (0.49) | PIK3CAGAAALKBH3PIK3CDPIK3CB | |
| SCHEMBL856240 | 0.88 | PIK3CA (0.46) | PIK3CACYP3A4CREBBP | |
| SCHEMBL861665 | 0.88 | PIK3CA (0.47) | PIK3CAFGFR1FGFR2FGFR3CREBBP | |
| SCHEMBL858460 | 0.87 | PIK3CA (0.45) | PIK3CAALKBH3ALDH1A1LMNACYP1A2 | |
| SCHEMBL858598 | 0.87 | PIK3CA (0.43) | PIK3CAALDH1A1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135568-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010135568-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |