Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.56 |
| ▸ | BRAF | P15056 | 8/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | MET | P08581 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828849 | 0.91 | KDR (0.54) | KDRBRAFAXLPDGFRBPDGFRA | |
| SCHEMBL573559 | 0.90 | KDR (0.56) | KDRBRAFAXLPDGFRBPDGFRA | |
| SCHEMBL574812 | 0.89 | KDR (0.55) | KDRBRAFAXLPDGFRBPDGFRA | |
| SCHEMBL574063 | 0.89 | KDR (0.55) | KDRBRAFAXLPDGFRBPDGFRA | |
| SCHEMBL574680 | 0.88 | KDR (0.54) | KDRBRAFAXLPDGFRBPDGFRA | |
| SCHEMBL573247 | 0.88 | KDR (0.63) | KDRBRAFAXLPDGFRBPDGFRA | |
| SCHEMBL574135 | 0.87 | KDR (0.53) | KDRBRAFAXLPDGFRBPDGFRA | |
| SCHEMBL572509 | 0.86 | KDR (0.64) | KDRBRAFAXLPDGFRBPDGFRA | |
| SCHEMBL573468 | 0.85 | KDR (0.54) | KDRBRAFPDGFRBPDGFRACSF1R | |
| SCHEMBL573472 | 0.85 | KDR (0.58) | KDRBRAFAXLPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146716-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008131227-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |