Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 6/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820730 | 0.90 | HRH4 (0.32) | HRH4HRH3GRM5ALDH1A1L3MBTL1 | |
| SCHEMBL3811763 | 0.90 | ESR2 (0.36) | GRM5ESR2ALDH1A1ESR1POLB | |
| SCHEMBL3812480 | 0.89 | GRM5 (0.33) | HRH4HRH3GRM5ALDH1A1L3MBTL1 | |
| SCHEMBL930144 | 0.84 | GRM5 (0.46) | GRM5ESR2ALDH1A1ESR1POLB | |
| SCHEMBL13720523 | 0.84 | GRM5 (0.35) | GRM5ESR2ALDH1A1ESR1POLB | |
| SCHEMBL3812748 | 0.84 | GRM5 (0.34) | HRH4HRH3GRM5ESR2ALDH1A1 | |
| SCHEMBL3813333 | 0.81 | ESR2 (0.35) | GRM5ESR2ALDH1A1ESR1POLB | |
| SCHEMBL3811200 | 0.81 | GRM5 (0.35) | HRH4HRH3GRM5ESR2ALDH1A1 | |
| SCHEMBL3817105 | 0.81 | SLC22A12 (0.40) | HRH4HRH3GRM5ALDH1A1TDP1 | |
| SCHEMBL3820261 | 0.81 | GRM5 (0.39) | HRH4HRH3GRM5ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |