Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 16/20 | 0.57 |
| ▸ | EGFR | P00533 | 12/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485031 | 0.90 | ERBB2 (0.62) | ERBB2EGFRKCNH2 | |
| SCHEMBL3812508 | 0.89 | ERBB2 (0.50) | ERBB2EGFRKCNH2 | |
| SCHEMBL4469684 | 0.88 | ERBB2 (0.74) | ERBB2EGFRKCNH2 | |
| SCHEMBL3812958 | 0.88 | EGFR (0.50) | ERBB2EGFRKCNH2 | |
| SCHEMBL3808108 | 0.88 | EGFR (0.53) | ERBB2EGFR | |
| SCHEMBL4475716 | 0.87 | ERBB2 (0.52) | ERBB2EGFRKCNH2 | |
| SCHEMBL4490078 | 0.87 | ERBB2 (0.53) | ERBB2EGFRKCNH2 | |
| SCHEMBL3812125 | 0.85 | ERBB2 (0.51) | ERBB2EGFRKCNH2 | |
| SCHEMBL3817146 | 0.83 | ERBB2 (0.69) | ERBB2EGFRKCNH2 | |
| SCHEMBL27627676 | 0.83 | ERBB2 (0.69) | ERBB2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631292-B1 | 4-ANILINO-QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2009-08-05 | — | — | EP | disclosed |
| US-20070149546-A1 | 4-Anilino-quinazoline derivatives as antiproliferative agents | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | disclosed |
| EP-1631292-A1 | 4-ANILINO-QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | Astra Zeneca AB (SE) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004093880-A1 | 4-ANILINO-QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149546-A1 | 4-Anilino-quinazoline derivatives as antiproliferative agents | ABL1, ERBB2, ERBB4 | ERBB2 2/4885EGFR 10/4885KCNH2 4713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.