Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 8/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.62 |
| ▸ | MET | P08581 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 8/20 | 0.56 |
| ▸ | AXL | P30530 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573919 | 0.90 | CSF1R (0.60) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL574103 | 0.89 | CSF1R (0.62) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL573993 | 0.89 | CSF1R (0.61) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL574230 | 0.89 | CSF1R (0.61) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL573851 | 0.87 | CSF1R (0.60) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL2926499 | 0.87 | CSF1R (0.72) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL573961 | 0.86 | CSF1R (0.58) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL572608 | 0.84 | KDR (0.61) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL3808740 | 0.84 | CSF1R (0.56) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL573549 | 0.83 | CSF1R (0.60) | CSF1RPDGFRAPDGFRBMETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146716-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008131227-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |