Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.53 |
| ▸ | PDE4A | P27815 | 11/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2528414 | 0.87 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2528257 | 0.85 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2529478 | 0.82 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL7865697 | 0.82 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2527878 | 0.82 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2531708 | 0.80 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2527842 | 0.79 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2528821 | 0.79 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2527944 | 0.79 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2526152 | 0.79 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2187893-A2 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | Anacor Pharmaceuticals, Inc. (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009111676-A2 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC (US) | 2009-09-11 | — | — | WO | disclosed |