Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 8/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.44 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL1983793 | 0.97 | NTRK1 (0.46) | NTRK1NTRK3NTRK2FLT3AURKA | |
| SCHEMBL1984971 | 0.93 | NTRK1 (0.52) | NTRK1NTRK3NTRK2FLT3AURKA | |
| SCHEMBL1983315 | 0.89 | NTRK1 (0.49) | NTRK1NTRK3NTRK2FLT3AURKA | |
| SCHEMBL1985453 | 0.85 | FLT3 (0.47) | NTRK1NTRK3NTRK2FLT3AURKA | |
| SCHEMBL1984697 | 0.82 | NTRK1 (0.52) | NTRK1NTRK3NTRK2FLT3AURKA | |
| SCHEMBL3485502 | 0.80 | FLT3 (0.49) | NTRK1NTRK3NTRK2FLT3AURKA | |
| SCHEMBL1984780 | 0.79 | CCNA2 (0.58) | NTRK1NTRK3NTRK2FLT3AURKA | |
| SCHEMBL1984817 | 0.78 | NTRK1 (0.47) | NTRK1NTRK3NTRK2FLT3AURKA | |
| SCHEMBL1983212 | 0.76 | AURKA (0.60) | NTRK1NTRK3NTRK2FLT3AURKA | |
| SCHEMBL3485388 | 0.76 | NTRK1 (0.58) | NTRK1NTRK3NTRK2FLT3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089394-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2009-08-19 | — | — | EP | claimed |
| WO-2008043745-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-04-17 | — | — | WO | claimed |
| EP-2089394-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008043745-A1 | SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-04-17 | — | — | WO | disclosed |