SCHEMBL381254

SCHEMBL381254

O=C1CC=Cc2o[c]nc21

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL498033 0.61
SCHEMBL223205 0.60
SCHEMBL2230333 0.59
SCHEMBL9665002 0.59
SCHEMBL4892384 0.59
SCHEMBL4371910 0.57
SCHEMBL11105462 0.56
SCHEMBL353445 0.56 PTPRC (0.31)
SCHEMBL447698 0.56
SCHEMBL18032691 0.56 GSK3A (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016054807-A1 TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF MERCK SHARP & DOHME CORP. (US) 2016-04-14 WO claimed
JP-4838934-B2 2011-12-14 JP claimed
WO-2007014054-A2 BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR GLAXO GROUP LIMTED (GB) 2007-02-01 WO claimed
EP-1042291-B1 ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS KLINGE CO CHEM PHARM FAB (DE) 2005-07-13 EP claimed
US-6200961-B1 FREE OF VOLATILE ORGANIC COMPOUNDS, STABILITY; FOR CONTROLLING INSECTS AQUATROLS CORPORATION OF AMERICA, INC. 2001-03-13 US claimed
EP-1043927-A1 AGROCHEMICAL EMULSIFIABLE CONCENTRATES Aquatrols Holding Co., Inc. (US) 2000-10-18 EP claimed
EP-1042291-A1 ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS Klinge Pharma GmbH (DE) 2000-10-11 EP claimed
WO-1999033340-A1 AGROCHEMICAL EMULSIFIABLE CONCENTRATES AQUATROLS HOLDING CO., INC. (US) 1999-07-08 WO claimed
WO-1999031064-A1 ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS KLINGE PHARMA GMBH (DE) 1999-06-24 WO claimed
EP-2137162-B1 ORGANIC COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2018-08-01 EP disclosed
WO-2016054807-A1 TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF MERCK SHARP & DOHME CORP. (US) 2016-04-14 WO disclosed
EP-2946014-A2 SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES Moderna Therapeutics, Inc. (US) 2015-11-25 EP disclosed
EP-2931914-A1 MODIFIED POLYNUCLEOTIDES FOR ALTERING CELL PHENOTYPE Moderna Therapeutics, Inc. (US) 2015-10-21 EP disclosed
EP-2793906-A2 METHODS OF INCREASING THE VIABILITY OR LONGEVITY OF AN ORGAN OR ORGAN EXPLANT Moderna Therapeutics, Inc. (US) 2014-10-29 EP disclosed
EP-1079832-A1 USE OF VITAMIN PP COMPOUNDS Klinge Pharma GmbH (DE) 2001-03-07 EP disclosed
EP-1043927-A1 AGROCHEMICAL EMULSIFIABLE CONCENTRATES Aquatrols Holding Co., Inc. (US) 2000-10-18 EP disclosed
EP-1042291-A1 ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS Klinge Pharma GmbH (DE) 2000-10-11 EP disclosed
WO-1999053920-A1 USE OF VITAMIN PP COMPOUNDS KLINGE PHARMA GMBH (DE) 1999-10-28 WO disclosed
WO-1999033340-A1 AGROCHEMICAL EMULSIFIABLE CONCENTRATES AQUATROLS HOLDING CO., INC. (US) 1999-07-08 WO disclosed
WO-1999031064-A1 ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS KLINGE PHARMA GMBH (DE) 1999-06-24 WO disclosed