Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.64 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | ESRRG | P62508 | 7/20 | 0.55 |
| ▸ | ESRRB | O95718 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3810879 | 0.94 | ESR1 (0.67) | ESR1ESR2CYP19A1ESRRGESRRB | |
| SCHEMBL3814022 | 0.90 | ESR1 (0.68) | ESR1ESR2CYP19A1ESRRGESRRB | |
| SCHEMBL3827799 | 0.88 | ESR1 (0.70) | ESR1ESR2CYP19A1PTGS2ESRRG | |
| SCHEMBL3815052 | 0.86 | ESR1 (0.59) | ESR1ESR2CYP19A1PTGS2ESRRG | |
| SCHEMBL3809275 | 0.85 | ESR1 (0.69) | ESR1ESR2CYP19A1PTGS2ESRRG | |
| SCHEMBL4674036 | 0.85 | ESR1 (0.69) | ESR1ESR2CYP19A1PTGS2ESRRG | |
| SCHEMBL3810848 | 0.84 | ESR1 (0.68) | ESR1ESR2CYP19A1ESRRGESRRB | |
| SCHEMBL5073339 | 0.82 | ESR1 (0.74) | ESR1ESR2ESRRGESRRBCYP3A4 | |
| SCHEMBL4667623 | 0.81 | ESR1 (0.52) | ESR1ESR2PTGS2 | |
| SCHEMBL3814114 | 0.81 | ESR1 (0.52) | ESR1ESR2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951217-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-08-12 | — | — | EP | claimed |
| EP-1951217-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007062148-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | claimed |
| EP-1951217-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-08-12 | — | — | EP | disclosed |
| US-20080234199-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-25 | — | — | US | disclosed |
| US-20080234199-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-25 | — | — | US | disclosed |
| US-20080234199-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-25 | — | — | US | disclosed |
| EP-1951217-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062148-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234199-A1 | Chemical Compounds | GPER1, ESR2, ESR1 | ESR1 3/4885ESR2 2/4885CYP19A1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.