Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815345 | 0.93 | MAPK14 (0.52) | MAPK14MAPK11KDRMAPK13MAPK12 | |
| SCHEMBL3817610 | 0.89 | MAPT (0.45) | MAPK14MAPK11KDRMAPK13MAPK12 | |
| SCHEMBL3317213 | 0.89 | MAPK14 (0.49) | MAPK14MAPK11KDRMAPK13MAPK12 | |
| SCHEMBL3822336 | 0.89 | MAPK14 (0.46) | MAPK14MAPK11KDRMAPK13MAPK12 | |
| SCHEMBL3822142 | 0.88 | MAPK14 (0.42) | MAPK14MAPK11KDRMAPK13MAPK12 | |
| SCHEMBL3819972 | 0.88 | MAPK14 (0.47) | MAPK14MAPK11KDRMAPK13MAPK12 | |
| SCHEMBL3820171 | 0.88 | MAPK14 (0.49) | MAPK14MAPK11KDRMAPK13MAPK12 | |
| SCHEMBL3814382 | 0.88 | MAPK14 (0.47) | MAPK14MAPK11KDRMAPK13MAPK12 | |
| SCHEMBL3820489 | 0.87 | MAPK14 (0.49) | MAPK14MAPK11KDRLCKKIT | |
| SCHEMBL3818023 | 0.87 | MAPK14 (0.45) | MAPK14MAPK11KDRMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635824-B1 | 5-MEMBERED HETEROCYCLE-BASED P-38 INHIBITORS | NOVARTIS AG (CH) | 2009-08-19 | — | — | EP | claimed |