Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.54 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725382 | 0.94 | PIK3CA (0.54) | PIK3CAGPR142CYP2D6CREBBPHSD11B1 | |
| SCHEMBL3792930 | 0.94 | PIK3CA (0.54) | PIK3CAGPR142CYP2D6CREBBPHSD11B1 | |
| SCHEMBL3798622 | 0.93 | PIK3CA (0.55) | PIK3CAGPR142CREBBPHSD11B1 | |
| SCHEMBL3791617 | 0.91 | PIK3CA (0.56) | PIK3CACREBBPHSD11B1 | |
| SCHEMBL2726522 | 0.91 | PIK3CA (0.53) | PIK3CAGPR142CREBBPHSD11B1HCRTR1 | |
| SCHEMBL2725196 | 0.90 | PIK3CA (0.56) | PIK3CAGPR142CREBBPHSD11B1 | |
| SCHEMBL2733019 | 0.90 | PIK3CA (0.57) | PIK3CAGPR142CREBBPHSD11B1 | |
| SCHEMBL6126363 | 0.89 | PIK3CA (0.56) | PIK3CAGPR142CREBBPHSD11B1 | |
| SCHEMBL7881809 | 0.89 | PIK3CA (0.56) | PIK3CAGPR142CREBBPHSD11B1 | |
| SCHEMBL2724235 | 0.89 | PIK3CA (0.56) | PIK3CAGPR142CREBBPHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138490-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138490-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2010-12-02 | — | — | WO | disclosed |