Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.93 |
| ▸ | HRH4 | Q9H3N8 | 17/20 | 0.66 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL603461 | 1.00 | HRH3 (0.93) | HRH3HRH4CCNT1CDK9 | |
| SCHEMBL603651 | 0.96 | HRH3 (1.00) | HRH3HRH4 | |
| SCHEMBL604562 | 0.96 | HRH3 (1.00) | HRH3HRH4 | |
| SCHEMBL603650 | 0.96 | HRH3 (1.00) | HRH3HRH4 | |
| SCHEMBL12853488 | 0.90 | HRH3 (0.88) | HRH3HRH4 | |
| SCHEMBL12853486 | 0.88 | HRH3 (0.85) | HRH3HRH4 | |
| SCHEMBL605598 | 0.87 | HRH3 (0.74) | HRH3HRH4 | |
| SCHEMBL605597 | 0.87 | HRH3 (0.74) | HRH3HRH4 | |
| SCHEMBL607490 | 0.86 | HRH3 (0.74) | HRH3HRH4 | |
| SCHEMBL4057382 | 0.86 | HRH3 (0.74) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233904-A1 | Macrocyclic Spiro Pyrimidine Derivatives | ABBOTT LABORATORIES (US) | 2009-09-17 | — | — | US | claimed |
| US-8278313-B2 | Macrocyclic spiro pyrimidine derivatives | ABBOTT LABORATORIES (US) | 2012-10-02 | — | — | US | disclosed |
| US-20090233904-A1 | Macrocyclic Spiro Pyrimidine Derivatives | ABBOTT LABORATORIES (US) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233904-A1 | Macrocyclic Spiro Pyrimidine Derivatives | DPYD, TYMS, TYMP | HRH3 4454/4885HRH4 4235/4885CCNT1 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.