Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3819882 | 1.00 | HRH4 (0.43) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL604077 | 0.90 | HRH4 (0.52) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL605645 | 0.90 | HRH4 (0.52) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL604078 | 0.90 | HRH4 (0.52) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL604076 | 0.90 | HRH4 (0.52) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL605644 | 0.90 | HRH4 (0.52) | HRH4HRH3KCNH2HRH1HRH2 | |
| Trifluoroacetic Acid SCHEMBL3816454 | 0.90 | HRH3 (0.35) | HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL3816458 | 0.90 | HRH3 (0.35) | HRH4HRH3 | |
| SCHEMBL603305 | 0.82 | HRH4 (0.64) | HRH4HRH3KCNH2 | |
| SCHEMBL604968 | 0.82 | HRH4 (0.64) | HRH4HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278311-B2 | Substituted pyrimidine derivatives | ABBOTT LABORATORIES (US) | 2012-10-02 | — | — | US | disclosed |
| US-20090270364-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270364-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES | DPYD, TYMP, TYMS | HRH4 1147/4885HRH3 713/4885KCNH2 2835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.