SCHEMBL3820565

SCHEMBL3820565

COC(=O)COC1CCCCC1C

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.41
EPHX2 P34913 4/20 0.38
NPSR1 Q6W5P4 2/20 0.37
ALDH1A1 P00352 3/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
POLB P06746 1/20 0.35
PTGDR Q13258 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.35
GLA P06280 1/20 0.35
HPGD P15428 1/20 0.35
EPHX1 P07099 2/20 0.34
TSHR P16473 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 1/20 0.32
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13003067 0.82 CYP19A1 (0.49) CYP19A1EPHX2NPSR1ALDH1A1L3MBTL1
SCHEMBL12936696 0.81 CYP19A1 (0.40) CYP19A1NPSR1ALDH1A1L3MBTL1POLB
SCHEMBL6744618 0.81 CYP19A1 (0.40) CYP19A1NPSR1ALDH1A1L3MBTL1POLB
SCHEMBL14521096 0.77 CYP19A1 (0.36) CYP19A1NPSR1ALDH1A1L3MBTL1HPGD
SCHEMBL12936708 0.77 CYP19A1 (0.36) CYP19A1NPSR1ALDH1A1L3MBTL1HPGD
SCHEMBL15120686 0.76 EPHX2 (0.42) EPHX2NPSR1PTGDRPTGDR2GLA
SCHEMBL7733269 0.75 EPHX2 (0.33) EPHX2NPSR1ALDH1A1PTGDRPTGDR2
SCHEMBL5605721 0.75 EPHX2 (0.44) EPHX2NPSR1PTGDRPTGDR2GLA
SCHEMBL27981419 0.74 CYP19A1 (0.35) CYP19A1ALDH1A1L3MBTL1HPGDEPHX1
SCHEMBL7733263 0.74 MEN1 (0.41) EPHX2NPSR1ALDH1A1PTGDRPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090280977-A1 PROCESS FOR PREPARING CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L (IT) 2009-11-12 US disclosed
EP-1355955-B1 CATALYST FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE SRL (IT) 2009-08-26 EP disclosed
EP-2051999-A1 PROCESS FOR PREPARING CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS Basell Poliolefine Italia S.r.l. (IT) 2009-04-29 EP disclosed
WO-2008019802-A1 PROCESS FOR PREPARING CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (DE) 2008-02-21 WO disclosed
US-6906154-B2 Catalyst for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2005-06-14 US disclosed
EP-1355955-A1 CATALYST FOR THE POLYMERIZATION OF OLEFINS Basell Poliolefine Italia S.p.A. (IT) 2003-10-29 EP disclosed
US-20030027715-A1 Catalyst for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.P.A (IT) 2003-02-06 US disclosed
EP-0790260-B1 Solid catalyst components for polymerization JAPAN POLYOLEFINS CO LTD (JP) 2002-11-06 EP disclosed
WO-2002044219-A1 CATALYST FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2002-06-06 WO disclosed
EP-0849291-B1 Catalyst for olefin polymerization and method for preparing polyolefins JAPAN POLYOLEFINS CO LTD (JP) 2002-02-13 EP disclosed
US-5693729-A STEREOSPECIFIC CATALYZING IN PRESENCE OF A MIXTURE CONSISTING OF A TITANIUM AND A MAGNESIUM COMPOUND, AN ORGANOALUMINUM COMPOUND OR AN ALUMOXANE, AN ORGANOSILICON COMPOUND SHOWA DENKO K.K. (JP) 1997-12-02 US disclosed
EP-0578473-B1 Catalyst for polymerization of olefin and process for producing olefin polymer SHOWA DENKO KK (JP) 1997-11-19 EP disclosed
EP-0790260-A1 Solid catalyst components for polymerization JAPAN POLYOLEFINS CO., LTD. (JP) 1997-08-20 EP disclosed
EP-0640624-B1 Catalyst for polymerization of olefin and process for the preparation of olefin polymer SHOWA DENKO KK (JP) 1997-06-18 EP disclosed
EP-0717053-A2 Catalyst for olefin polymerization and process for producing polyolefin using the same JAPAN POLYOLEFINS CO., LTD. (JP) 1996-06-19 EP disclosed
EP-0704424-A1 3-alkoxypropionic ester derivative, olefin polymerization catalyst, and process for preparation of polyolefin SHOWA DENKO KABUSHIKI KAISHA (JP) 1996-04-03 EP disclosed
US-5476825-A Consists of magnesium, titanium and halogen compounds, an organoaluminum compound, a reaction product of organoaluminum or organoboron compound with organosilicon compound SHOWA DENKO K.K. (JP) 1995-12-19 US disclosed
US-5407883-A Containing magnesium, titanium, aluminum and silicon compounds including polymeric aluminum and alumoxanes SHOWA DENKO K.K. (JP) 1995-04-18 US disclosed
EP-0640624-A1 Catalyst for polymerization of olefin and process for the preparation of olefin polymer SHOWA DENKO KABUSHIKI KAISHA (JP) 1995-03-01 EP disclosed
EP-0578473-A1 Catalyst for polymerization of olefin and process for producing olefin polymer SHOWA DENKO KABUSHIKI KAISHA (JP) 1994-01-12 EP disclosed