Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.54 |
| ▸ | ATR | Q13535 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459975 | 0.91 | USP30 (0.55) | USP30ATR | |
| SCHEMBL3462390 | 0.89 | ATR (0.55) | ATR | |
| SCHEMBL3460822 | 0.89 | ATR (0.54) | ATR | |
| SCHEMBL3831526 | 0.88 | USP30 (0.49) | USP30ATR | |
| SCHEMBL3459791 | 0.88 | USP30 (0.49) | USP30ATR | |
| SCHEMBL3460934 | 0.87 | USP30 (0.49) | USP30ATRLMNA | |
| SCHEMBL3461563 | 0.86 | ATR (0.58) | USP30ATRLMNA | |
| SCHEMBL3461383 | 0.86 | USP30 (0.48) | USP30ATR | |
| SCHEMBL3460686 | 0.86 | USP30 (0.48) | USP30ATR | |
| SCHEMBL3462372 | 0.86 | ATR (0.59) | USP30ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |