Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | NMBR | P28336 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1039638 | 0.89 | SIRT2 (0.43) | SIRT2CYP11B1CYP11B2NMBR | |
| SCHEMBL1039740 | 0.85 | SIRT2 (0.43) | SIRT2CYP11B1CYP11B2NMBR | |
| SCHEMBL2796109 | 0.82 | SIRT2 (0.52) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL7084063 | 0.81 | SIRT2 (0.43) | SIRT2CYP11B1CYP11B2NMBRENPP2 | |
| SCHEMBL1037597 | 0.81 | SIRT2 (0.45) | SIRT2CYP11B1CYP11B2NMBRENPP2 | |
| SCHEMBL2490264 | 0.80 | SIRT2 (0.48) | SIRT2CYP11B1CYP11B2NMBRENPP2 | |
| SCHEMBL7974401 | 0.80 | SIRT2 (0.43) | SIRT2 | |
| SCHEMBL8165853 | 0.79 | SIRT2 (0.47) | SIRT2CYP11B1CYP11B2NMBRENPP2 | |
| SCHEMBL1309013 | 0.79 | SIRT2 (0.47) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL2032778 | 0.79 | SIRT2 (0.47) | SIRT2CYP11B1CYP11B2NMBRENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106640-A2 | N-BENZYL IMIDAZOLE DERIVATIVES | MAASTRICHT UNIVERSITY (NL) | 2009-09-03 | — | — | WO | disclosed |
| EP-2095819-A1 | N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors | Maastricht University (NL) | 2009-09-02 | — | — | EP | disclosed |