Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 8/20 | 0.43 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.42 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776932 | 0.85 | MAP2K1 (0.75) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3818910 | 0.85 | MAP2K1 (0.53) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3817487 | 0.82 | MAP2K1 (0.61) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3819429 | 0.78 | MAP2K1 (0.47) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3813540 | 0.78 | MAP2K1 (0.47) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL1488319 | 0.77 | MAP2K2 (0.73) | MAP2K1MAP2K2 | |
| SCHEMBL30220910 | 0.77 | MAP2K2 (0.73) | MAP2K1MAP2K2 | |
| SCHEMBL1776722 | 0.71 | MAP2K1 (1.00) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL1776529 | 0.70 | MAP2K1 (0.73) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL1775393 | 0.70 | MAP2K1 (1.00) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089359-A2 | MAPK/ERK KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2009-08-19 | — | — | EP | claimed |
| WO-2008055236-A2 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-08 | — | — | WO | claimed |
| EP-2089359-A2 | MAPK/ERK KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008055236-A2 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-08 | — | — | WO | disclosed |