Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 19/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 18/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819198 | 0.90 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL3255444 | 0.90 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL3820659 | 0.88 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL3817821 | 0.87 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL3823635 | 0.87 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3828625 | 0.87 | HCRTR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL3820992 | 0.86 | HCRTR1 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL3828272 | 0.86 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3835207 | 0.85 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL3819678 | 0.83 | HCRTR1 (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094690-A2 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2009-09-02 | — | — | EP | claimed |
| WO-2008081399-A2 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-10 | — | — | WO | claimed |
| EP-2094690-A2 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008081399-A2 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-10 | — | — | WO | disclosed |