Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | HTT | P42858 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MMP14 | P50281 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17960032 | 0.87 | HIF1A (0.50) | HIF1AALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL4042845 | 0.85 | HIF1A (0.48) | HIF1AALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL1811084 | 0.83 | HIF1A (0.49) | HIF1AALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL1811826 | 0.83 | HIF1A (0.46) | HIF1AALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL4037188 | 0.82 | HIF1A (0.45) | HIF1AALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL12622768 | 0.80 | HIF1A (0.46) | HIF1AALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL12622766 | 0.80 | HIF1A (0.44) | HIF1AALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL17960012 | 0.79 | HIF1A (0.43) | HIF1AALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL17960040 | 0.79 | MEN1 (0.43) | HIF1AALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL1815491 | 0.79 | HIF1A (0.46) | HIF1AALDH1A1HTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539700-B1 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LTD (AU) | 2009-08-26 | — | — | EP | disclosed |