Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 11/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427607 | 0.91 | CNR1 (0.70) | CNR1KCNH2CNR2 | |
| SCHEMBL4469293 | 0.86 | CNR1 (0.74) | CNR1CNR2 | |
| SCHEMBL4474441 | 0.82 | CNR1 (0.68) | CNR1CNR2 | |
| SCHEMBL3827684 | 0.82 | CNR1 (0.70) | CNR1CNR2 | |
| SCHEMBL4074146 | 0.82 | KDM4E (0.65) | CNR1CNR2 | |
| SCHEMBL4481055 | 0.80 | CNR1 (0.72) | CNR1CNR2 | |
| SCHEMBL5345390 | 0.80 | CNR1 (1.00) | CNR1KCNH2CNR2 | |
| SCHEMBL4477764 | 0.78 | CNR1 (0.63) | CNR1CNR2 | |
| SCHEMBL4460301 | 0.76 | CNR1 (0.60) | CNR1CNR2 | |
| SCHEMBL219061 | 0.76 | KDM4E (0.69) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641763-B1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI AVENTIS (FR) | 2009-09-02 | — | — | EP | claimed |
| US-7521471-B2 | 4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof | SANOFI-AVENTIS (FR) | 2009-04-21 | — | — | US | claimed |
| US-20070293541-A1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2007-12-20 | — | — | US | claimed |
| US-20060135776-A1 | 4-Cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof | SANOFI-AVENTIS (FR) | 2006-06-22 | — | — | US | claimed |
| EP-1641763-B1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI AVENTIS (FR) | 2009-09-02 | — | — | EP | disclosed |
| US-7521471-B2 | 4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof | SANOFI-AVENTIS (FR) | 2009-04-21 | — | — | US | disclosed |
| US-20070293541-A1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2007-12-20 | — | — | US | disclosed |
| US-7282516-B2 | 4-cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof | SANOFI-AVENTIS (FR) | 2007-10-16 | — | — | US | disclosed |
| US-20060135776-A1 | 4-Cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof | SANOFI-AVENTIS (FR) | 2006-06-22 | — | — | US | disclosed |
| EP-1641763-A2 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES PREPARATION AND THERAPEUTIC APPLICATION THEREOF | Sanofi-Aventis (FR) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005000820-A2 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES PREPARATION AND APPLICATION THEREOF AS CB1 CANNABINOID ANTAGONISTS | SANOFI-AVENTIS (FR) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135776-A1 | 4-Cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof | CBR3, CNR1, CNR2 | CNR1 2/4885KCNH2 189/4885CNR2 3/4885 |
| US-20070293541-A1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF | CBR3, CNR1, CNR2 | CNR1 2/4885KCNH2 158/4885CNR2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.