Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.60 |
| ▸ | ATR | Q13535 | 13/20 | 0.60 |
| ▸ | PRKDC | P78527 | 6/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3462240 | 0.90 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3460519 | 0.86 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3460255 | 0.85 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3460561 | 0.85 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3460329 | 0.84 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3460514 | 0.84 | ATR (0.77) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3459728 | 0.83 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461330 | 0.82 | ATR (0.71) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461802 | 0.82 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3460013 | 0.81 | ATR (0.78) | PIK3CDPIK3CAPIK3CGPIK3CBATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | claimed |
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |