Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 5/20 | 0.38 |
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.35 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.35 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61869 | 1.00 | NOTUM (0.39) | NOTUMBCHEACHEELANECD274 | |
| SCHEMBL62614 | 1.00 | NOTUM (0.39) | NOTUMBCHEACHEELANECD274 | |
| SCHEMBL62043 | 0.87 | BCHE (0.36) | BCHEACHECD274ALDH1A1L3MBTL1 | |
| SCHEMBL63437 | 0.86 | BCHE (0.35) | BCHEACHEL3MBTL1C5AR1 | |
| SCHEMBL61659 | 0.85 | C5AR1 (0.37) | BCHEACHEMEN1KMT2AL3MBTL1 | |
| SCHEMBL62946 | 0.85 | C5AR1 (0.43) | BCHEACHEC5AR1 | |
| SCHEMBL63422 | 0.85 | BCHE (0.38) | BCHEACHEALDH1A1L3MBTL1C5AR1 | |
| SCHEMBL63953 | 0.84 | CD274 (0.41) | BCHEACHECD274ALDH1A1L3MBTL1 | |
| SCHEMBL63414 | 0.84 | BCHE (0.38) | BCHEACHEELANEALDH1A1L3MBTL1 | |
| SCHEMBL62238 | 0.84 | BCHE (0.38) | BCHEACHEALDH1A1L3MBTL1C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745033-A4 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORP (US) | 2009-08-26 | — | — | EP | claimed |
| CN-1976918-A | 4,5-disubstituted-2-aryl pyrimidines | NEUROGEN CORP (US) | 2007-06-06 | — | — | CN | claimed |
| EP-1745033-A2 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORPORATION (US) | 2007-01-24 | — | — | EP | claimed |
| WO-2005110416-A2 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |