Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 14/20 | 0.57 |
| ▸ | BIRC3 | Q13489 | 9/20 | 0.57 |
| ▸ | BIRC2 | Q13490 | 13/20 | 0.54 |
| ▸ | CASP9 | P55211 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13719137 | 0.93 | XIAP (0.58) | XIAPBIRC3BIRC2CASP9 | |
| SCHEMBL12465436 | 0.93 | XIAP (0.58) | XIAPBIRC3BIRC2CASP9 | |
| SCHEMBL12725506 | 0.92 | XIAP (0.55) | XIAPBIRC3BIRC2CASP9 | |
| SCHEMBL1633432 | 0.92 | XIAP (0.55) | XIAPBIRC3BIRC2CASP9 | |
| SCHEMBL3820356 | 0.89 | XIAP (0.59) | XIAPBIRC3BIRC2CASP9 | |
| SCHEMBL3810557 | 0.89 | XIAP (0.59) | XIAPBIRC3BIRC2CASP9 | |
| SCHEMBL3829687 | 0.87 | XIAP (0.48) | XIAPBIRC3BIRC2CASP9 | |
| SCHEMBL3825731 | 0.87 | XIAP (0.48) | XIAPBIRC3BIRC2CASP9 | |
| SCHEMBL3812779 | 0.87 | XIAP (0.52) | XIAPBIRC3BIRC2CASP9 | |
| SCHEMBL3812120 | 0.87 | XIAP (0.71) | XIAPBIRC3BIRC2CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874748-B1 | 2 -AMINOCARBONYL SUBSTITUTED PIPERAZINE OR DIAZA-CYCLIC COMPOUNDS AS APOPTOSIS PROTEIN INHIBITOR (IAP) MODULATORS | NOVARTIS AG (CH) | 2009-08-12 | — | — | EP | claimed |
| EP-1874748-B1 | 2 -AMINOCARBONYL SUBSTITUTED PIPERAZINE OR DIAZA-CYCLIC COMPOUNDS AS APOPTOSIS PROTEIN INHIBITOR (IAP) MODULATORS | NOVARTIS AG (CH) | 2009-08-12 | — | — | EP | disclosed |