Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.46 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 5/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461531 | 0.94 | USP30 (0.56) | USP30PARP1ACVR1ACVR2ATGFBR2 | |
| SCHEMBL3462072 | 0.91 | USP30 (0.53) | USP30PARP1ACVR1ACVR2ATGFBR2 | |
| SCHEMBL14314423 | 0.89 | ATR (0.48) | USP30ACVR1ACVR2ATGFBR2ATR | |
| SCHEMBL3462663 | 0.88 | ATR (0.51) | ACVR1ACVR2ATGFBR2ATRTYRO3 | |
| SCHEMBL3461780 | 0.85 | ATR (0.48) | USP30ACVR1ACVR2ATGFBR2ATR | |
| SCHEMBL3459975 | 0.84 | USP30 (0.55) | USP30ATR | |
| SCHEMBL14219173 | 0.83 | USP30 (0.47) | USP30PARP1ACVR2ATGFBR2ATR | |
| SCHEMBL1792224 | 0.83 | USP30 (0.47) | USP30PARP1ATRHDAC4HDAC6 | |
| SCHEMBL14219179 | 0.83 | USP30 (0.47) | USP30PARP1ACVR2ATGFBR2ATR | |
| SCHEMBL1791954 | 0.83 | USP30 (0.47) | USP30PARP1ATRHDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |