Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 9/20 | 0.52 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | FPR3 | P25089 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401190 | 1.00 | USP30 (0.52) | USP30PARP1HDAC4HDAC6PBK | |
| SCHEMBL3822820 | 0.97 | USP30 (0.49) | USP30PARP1HDAC4HDAC6PBK | |
| SCHEMBL14314422 | 0.89 | USP30 (0.51) | USP30PARP1HDAC4HDAC6PBK | |
| SCHEMBL13435411 | 0.85 | PIM1 (0.44) | USP30PARP1HDAC4HDAC6PBK | |
| SCHEMBL3819913 | 0.84 | PIM1 (0.47) | PIM1PIM3PIM2 | |
| SCHEMBL3460880 | 0.84 | PIM1 (0.47) | PIM1PIM3PIM2 | |
| SCHEMBL30841573 | 0.84 | BTK (0.49) | USP30PARP1HDAC4HDAC6PBK | |
| SCHEMBL3460821 | 0.81 | ACVR2A (0.47) | PIM1PIM3PIM2 | |
| SCHEMBL3461642 | 0.80 | BACE1 (0.48) | FPR3FPR2 | |
| SCHEMBL13472564 | 0.80 | USP30 (0.52) | USP30PARP1HDAC4HDAC6PBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |